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p3<5889sy>|q9s9gs|q+~q|s9x|q>gxϟ9<ϙ?3>gϞ|3s9>g>gyϟ"~όsy>g3:>g?<ϙ?0>g9 0s8?>g>gyϟ"~@sx>`02f>`? ϙ?0>g9 0y>O?'<>g>gyϟ&~@sx>`0O>p? ϙ?3>gϓ3y>O'?>g>gyϟǁ ~sy>g3O> ß?O >ϙ?3>ǵ?3y>O'?>g>gyϟ~|sy>g3_>ϟ?O&>yϘ9>sx?9>O'9>g>s|qϟς??<|yǞys|>s9|gx?&?Ϝ898>p8"?<>g>pϜxp~s>p8?px?&?ϟ yy>>x?<>"?>g>|'Ϝ|>x?s>|>?sx?~ߐdžߏǂ?σ{??σ>=<??ρ x8ς'ρ>Oρ>Oρ񟞁ς'ρ>Oρ>Oρ?~?ρς-'σO>OO>O!?<x y<ρ27N>o>o<`yLJ?8p >|q89?ρ2?s8x9yy|9?sg993ρ? 33~ρyy?sg983ρ? ə3&0~s  ?8xyǎx|?3?~8q3-τO8!9s<pg? ????7@*J:\DRAFTS\NRLOGO.WPGJ:\DRAFTS\NRLOGO.WPGhd\,3BV4d\,<l:Default ParaXXX<:Footnote Ref(5hCEKQW]cioAutoList11.1.1.1.1.1.1.1.3#37=CIQYag1.a.i.(1)(a)(i)1)a)(;3$2#  0  .3  0  (3$ !  ( $ Figure  1  1VZ  I&mage <=8C HKKKK !  _  ,j\76&"`z1% `E,,%y%y,,%j (#(#        (#(#ReleaseNo.0066.00 @  @`  @  @  @h Media_contact_:Maria_Bynum_,(202)7205192,maria.bynum@usda.gov @  @`  @  @  @h Publiccontact:SeanAdams,(301)5041622,% @  @`  @  @  @h  @ % @  @p _&issa&'sa'(d('ams'@asrr.arsusda.gov_C USDA,BRAZILTEAMUPTOFIGHTDENGUEVIRUS     WASHINGTON,Feb.29,2000TheU.S.DepartmentofAgricultureandBraziliangovernmentofficialstodaysignedanagreementtoconductajointresearchprojecttobiologicallycontroltheAedesaegyptimosquitothattransmitsDenguevirus. p   OurUSDAscientistsareamongtheforemostexpertsintheworldincontrollingthemosquitothattransmitsthisdisease,saidUnderSecretaryofAgricultureforResearch,Education,andEconomicsI._Miley_ԀGonzalezwhosignedtheagreementtoday. Wearehopefulthatwecansuppressthisdiseaseandimprovethehealthofpeopleinmorethan100countrieswherethisdiseaseisnowendemic.   `     h   Dengue,transmittedprimarilybytheyellowfevermosquitoA.aegypti,causesasevere,  flulikeillness.Thediseasehasspreadaroundtheworldinrecentyears,reachingepidemicproportionsinBrazilandotherpartsoftheworld,accordingtotheWorldHealthOrganization.WHOestimatestheremaybe50millioncasesofdengueworldwideeachyear.Themosquitohas  beenlargelyeliminatedfromtheUnitedStates,nowconfinedtothesouthernmostareasofFloridaandTexas.  Undertheagreement,thescientistswilluseabiologicalcontrolagentcalled_Edhazardia_ p!D # _aedis_,a_microsporidium_ԀdevelopedbyUSDAscientistsattheAgriculturalResearchServices \"0!$ CenterforMedical,AgriculturalandVeterinaryEntomology,inGainesville,Florida.󀀀Inthemid1990s,smallscalefieldtrialsusingE._aedis_intheUnitedStateswere  %#' successfulatcontrollingA.aegyptimosquitoesinFlorida,accordingtoDonaldBarnard,who  &$( headstheMosquitoandFlyResearchUnitat_CMAVE_.ResearchersareplanninglargerscaletrialsinBrazillaterthisyearandthenlargescalereleasesoftheorganismtocontrolthemosquito.  TheBrazilianMinisterofHealth,Jose_Serra_,andtheBrazilianAmbassadorRubens_Barbosa_,joinedGonzalezfortodayssigning.    # Contactfordetails:DonaldBarnard,CenterforMedical,AgriculturalandVeterinaryEntomology,Gainesville,Florida,phone(352)3745930,,XXXX?+ 4 <DL!X?dbarnard@gainesville.usda.ufl.edu 00/3 #XnXX,X`# 0104 _ԇ  "    IMPLEMENTINGARRANGEMENT  BETWEENTHEGOVERNMENTOFTHEFEDERATIVEREPUBLICOFBRAZILANDTHEGOVERNMENTOFTHEUNITEDSTATESOFAMERICAFORTHEBIOLOGICALCONTROLOFTHEAEDESAEGYPTIMOSQUITO   TheGovernmentoftheFederativeRepublicofBrazilandtheGovernmentoftheUnitedStatesofAmerica(hereafterreferredtoas Parties),Realizingtheexistenceofbroadbilateralinterestswithreferencetothepromotionofpublicandanimalhealth,andtothepreventionandcontrolof  mosquitobornediseases; <   Desiringtofostergreatercooperationintheareaofpublicandanimalhealthbetweenbothcountries;andRealizingtheimportanceofworkingtogetherwithaviewtoaddresstheproblemofbiologicalcontroloftheAedesaegyptimosquito.  ThePartieshaveagreedasfollows:    ARTICLEI  tH  PURPOSEANDSCOPEOFCOOPERATION `4  X  ?+ ` hp x (#X?  1.  ThepurposeofthisImplementingArrangementisthedevelopmentofajointresearch 8  projectofmutualinterestonnonchemicalmethodsforthecontrolofAedesaegypti $ mosquito,including:    9% hp x (#X9a. ` biologicalcontrol;and    b. ` newtechnologiesforattractionandtrappingofadultmosquitoes   B.` hp x (#  XB?+ ` hp x (#X? 2.  CooperationwilltakeplaceinaccordancewiththetermsofthisImplementing   Arrangement,whichprovidesaframeworktoencouragejointresearchactivitiestopromoteimprovementsinpublicandanimalhealth,subjecttothelawsandregulationsofeachcountry.  XB.` hp x (#XB X?+ ` hp x (#X? 3.  Cooperationshallrespectthoselawsconcerninghumansafetyandenvironment H#"% protectionineachPartiesterritories.  XB.` hp x (#XB X?+ ` hp x (#X? 4.  Activities,wherepossible,shouldbecoordinatedwith,orbesupportiveoftheactivities  &$( andgoalsofinternationalhealthbodies,includingtheWorldHealthOrganizationandthePanAmericanHealthOrganization.  X  B.` hp x (#XB ARTICLEII +h*. IMPLEMENTINGAUTHORITIES ,T+/  X  ?+ ` hp x (#X?  1.  ThisImplementingArrangementissubjecttoandgovernedbytheAgreementbetween X.,-1 theFederativeRepublicofBrazilandtheUnitedStatesofAmericaRelatingto CooperatinginScienceandTechnology,signedonFebruary6,1984,asamendedand 00/3 extended( theAgreement).ThePartieshaveagreedtoconcludethefollowingImplementingArrangementtocooperateinthecontroloftheAedesaegyptimosquito.  XB.` hp x (#XB X?+ ` hp x (#X? 2.  TheImplementingAuthoritiesofthisImplementingArrangementare,fortheFederative  RepublicofBrazil,theMinistriesofHealthandofScienceandTechnologyand,fortheUnitedStatesofAmerica,theU.S.DepartmentofAgriculture(USDA).     XB.` hp x (#XB   ARTICLEIII t METHODSOFCOOPERATION `  X  ?+ ` hp x (#X?  1.  CooperationunderthisImplementingArrangementshallconsistof: d 8    XB.` hp x (#XB <(` ` hp x (#X< a. ` Exchangeofscientificandtechnologicalinformation,identifiedasrelevantto <   implementationofthejointresearchproject;  B.` hp x (#` ` XB <(` ` hp x (#X< b. ` Trainingactivitiesrelatedtoquarantineprocedures,maintenanceof_Edhazardia_   _aedis_,thelivingorganismthatwillfighttheAedesaegyptimosquito,andother  activitiesdeemednecessarytoaccomplishtheexpectedresults;  B.` hp x (#` ` XB <(` ` hp x (#X< c. ` Developmentofdatabasesonmosquitoseasonalabundanceandactivity,  includingthedevelopmentoftechniques,proceduresandschedulesforlongtermmonitoringofmosquitopopulations.  B.` hp x (#` ` XB <(` ` hp x (#X< d. ` IdentificationoftargetsitesinBrazilforreleaseof_Edhazardia_Ԁ_aedis_andsurveyof `4 thesesitesforthepresenceofendemicpathogensandparasitesofAedesaegypti; L   B.` hp x (#` ` XB X 8   <(` ` hp x (#X< Xe. ` Releaseof_Edhazardia_Ԁ_aedis_intothemosquitopopulationattargetedsites; $   B.` hp x (#` ` XB <(` ` hp x (#X< f. ` Monitoringofinfectionratesinthemosquitopopulation,dispersalofthe  pathogenthroughthemosquitopopulationandchangesinmosquitopopulationdensitythroughtime,preferablybycomparisonwithuntreatedsites;  B.` hp x (#` ` XB <(` ` hp x (#X< g. ` Augmentativeperiodicreleases,asdeemednecessaryinthefirstyearof   cooperationtoachievethedesiredlevelofinfectioninthemosquitopopulation;  B.` hp x (#` ` XB <(` ` hp x (#X< h. ` Monitoringofinfectionlevelsofthepathogeninthemosquitopopulationinthe p!D # secondandsucceedingyearsinwhichthisImplementingArrangementisinforce;  B.` hp x (#` ` XB <(` ` hp x (#X< _i_. ` Trainingofpostgraduatestudentsinareasrelatedtothescopeofthiscooperation. 4$#&  X?+ ` hp x (#` ` X?2.  Targetsitesforreleaseofthepathogenaremostlikelytobeurbanandsuburbanareas  %#' infestedwithAedesaegyptiandwithoutactivedenguetransmission.  &$(   XB.` hp x (#XB X?+ ` hp x (#X? 3.  Additionalreleasesofthepathogenmaybedoneifnecessary,atthebeginningof,and '&* duringthemosquitoseasonforthefirstfive(5)yearsoftheproject.  ('+   XB.` hp x (#XB   ARTICLEIV *|)- ORGANIZATIONOFCOOPERATION +h*.  X  ?+ ` hp x (#X?  1.  TheMinistryofHealthofBrazildesignatestheExecutiveSecretaryoftheAedesaegypti l-@,0 EradicationProgramascoordinatorforjointresearchunderthisImplementingArrangement.  XB.` hp x (#XB 00/3 _ X?+ ` hp x (#X? 2.  TheUnitedStatesDepartmentofAgriculturedesignatesascoordinatorforjointresearch ,  underthisImplementingArrangement,itsResearchLeaderoftheMosquitoandFlyResearchUnit,Gainesville,Florida.  XB.` hp x (#XB X?+ ` hp x (#X? 3.  Thecoordinatorsshallalsodeterminetheinstitutionsonbothsidesfortheexecutionof  theprojectandtheextentoftheirparticipation.  XB.` hp x (#XB X?+ ` hp x (#X? 4.  ThePartiesshallestablishaSteeringCommitteecomposedofthecoordinatorsand t representativesoftheImplementingAuthoritiestoassessthedevelopmentofcooperationunderthisImplementingArrangement.RepresentativesofothergovernmentalsectorsofbothPartiesmaybeinvitedtoparticipateasobservers.  XB.` hp x (#XB X?+ ` hp x (#X? 5.  TheSteeringCommitteeshallmeetatleastonceayeartoevaluateresearchprogressand <   reviewworkplansforthenextresearchperiod.  XB.` hp x (#XB  ARTICLEV   ЀOBLIGATIONSOFTHEPARTIES     1.  TheBrazilianPartyagreesto:   <(` ` hp x (#X< a. ` Collaborateintheexchangeofdataandprogressreportsforthejointresearch p projectandinotheractivitiesthatmayfacilitateitsprogress;  B.` hp x (#` ` XB <(` ` hp x (#X< b. ` Obtainpermission,subjecttonationallawsandregulations,toimportEdhazardia `4 aedisintoBrazilianterritory; L    B.` hp x (#` ` XB <(` ` hp x (#X< c. ` ProvideadequatefacilitiesandservicesinBrazilforjointresearchactivities, $ mainlythoseneededforquarantine,massproductionandreleaseofthepathogen;  B.` hp x (#` ` XB <(` ` hp x (#X< d. ` AssignandprovideBrazilianpersonneltobeinvolvedinresearchandtraining  activities;e. ` SelecttargetsitesinBrazilforreleaseofEdhazardiaaedis;  <(` ` hp x (#` ` X<f. ` Collaborateforthedevelopmentofdatabasesonmosquitoseasonalabundance   andactivity;  B.` hp x (#` ` XB <(` ` hp x (#X< g. ` Makethenecessaryreleasesforthepathogenintomosquitopopulationsattarget p!D # sites;and  B.` hp x (#` ` XB <(` ` hp x (#X< h. ` Monitorinfectionratesinmosquitopopulationsattargetsites. 4$#&   B.` hp x (#` ` XB2.  TheU.S.Partyagreesto:  &$(  <(` ` hp x (#X< a. ` ProvideinformationasneededfortheimportofEdhazardiaaedisintoBrazilian '&* territory,incompliancewithBrazilianlaw.  B.` hp x (#` ` XB <(` ` hp x (#X< b. ` Providethebiologicalcontrolagentasmutuallyagreedupon; *|)-  B.` hp x (#` ` XB X +h*.  <(` ` hp x (#X< Xc. ` ProvidetrainingforBrazilianpersonnelinallproceduresandtechniquesdeemed ,T+/ necessaryforresearchdevelopment,includingbutnotlimitedto: X.,-1   B.` hp x (#` ` XB   `  1)  quarantinemanagement; D/.2  2)  maintenanceofEdhazardiaaedis; 00/3  ` 6" hp x (#X6 3)  massproductionofthepathogen; 1/4 4)  releaseofthepathogenintomosquitopopulations; , 5)  monitoringofinfectionratesamongmosquitopopulations.    ` B.` hp x (#XB <(` ` hp x (#X< d. ` Provideguidanceandconsultonactivitiesrelatedtomaintenanceofthebiological  controlagentinBrazil;  B.` hp x (#` ` XB <(` ` hp x (#X< e. ` CollaborateintheselectionoftargetsitesforreleaseofthepathogeninBrazil;   B.` hp x (#` ` XB X t  <(` ` hp x (#X< Xf. ` Collaborateindevelopmentofdatabasesonmosquitoseasonalabundanceand ` activityattargetsites;  B.` hp x (#` ` XB <(` ` hp x (#X< g. ` Providethenecessaryfacilitiesandservicesforimplementationofactivitieson P $   ` U.S.territory,includingtrainingofBrazilianpersonnel;  B.` hp x (#` ` XB <(` ` hp x (#X< h. ` Collaboratetoimplementproceduresandtechniquesfortheidentificationof   Edhazardiaaedisinfectioninmosquitopopulations;and    B.` hp x (#` ` XB X   <(` ` hp x (#X< Xi. ` Collaborateintheexchangeofdataandprogressreportsforthejointresearch  projectandinotheractivitiesthatmayfacilitateitsprogress. _    B.` hp x (#` ` XB  ARTICLEVI  ,  OPERATIONALASPECTS     BothPartiesagreethat:1.  ResearchworkshallbeplannedandexecutedjointlybytheImplementingAuthorities;  B.` hp x (#XBL >5h(3?L @3   @3U25h  2  .3  0    TheBrazilianpartyshallpresentadraftofaGeneralWorkPlan,withinonemonthafter t signatureofthisImplementingArrangementtotheU.S.party.Onceitscontenthasbeenmutuallyagreedupon,thisGeneralWorkPlanshallbedetailedand,whenevernecessary,reviewedtobepresentedforanalysisbytheSteeringCommittee;and@3UU݌ (#(# Ќ  B.` hp x (#XB @3   @36X25h  3  .3  0    Acompletereportoftheresultsofresearchworkaswellasannualprogressreportsshall <   bepreparedbythecoordinatorstobesubmittedtotheSteeringCommitteeforassessment.@36XaX݌ (#(# Ќ  B.` hp x (#XB   `    ARTICLEVII  INFORMATIONANDPUBLICATION    X  ?+ ` hp x (#X? 1.  Allscientificandtechnicalinformationarisingoutofcooperationestablishedunderthis  ImplementingArrangementmaybepublishedormadeavailablebytheImplementingAuthorities,jointlyorindividually,afterconsultationbetweenthecoordinatorsaboutthesubstanceofthematerialtobedisclosed.  XB.` hp x (#XB X?+ ` hp x (#X? 2.  Totheextentpermittedbytherespectivelawsofeachcountry,noconfidential L  informationexchangedpursuanttoorarisingoutoftheactivitiesunderthisImplementingArrangement,meaninginformationrequiringprotectionintheinterestsofnationaldefenseorforeignrelationsofeithercountryorinformationthatcanaffectthepreservationofinventionrights,shallbepublishedormadepubliclyavailable.  XB.` hp x (#XB X?+ ` hp x (#X? 3.  AllinformationtobereleasedconcerningworkcarriedoutunderthisImplementing  ArrangementshallacknowledgecontributionsofeachPartytotheresearcheffort.     XB.` hp x (#XB  ARTICLEVIII l! ЀINTELLECTUALPROPERTYRIGHTSANDSECURITYOBLIGATIONS  X"   IntellectualPropertyRightsandSecurityObligationsshallbegovernedbytheprovisionsof \"0!$ AnnexesIandIIoftheAgreementbetweentheFederativeRepublicofBrazilandtheUnitedStatesofAmericaRelatingtoCooperationinScienceandTechnology,ofFebruary6,1984,asamendedandextended.  "#""#""#""#""#""#""#""#""#""#""$$"ARTICLEIX &%) FINANCING '&*  X  ?+ ` hp x (#X?   ('+ 1.  EachPartyshallberesponsibleforthecostsofitsownparticipation,including )(, appropriatekindsofinsurance,subjecttotheavailabilityoffinancialresources,exceptincaseofwrittenagreementsettingforthotherconditions.  XB.` hp x (#XB X?+ ` hp x (#X? 2.  ExpensesrelatedtotheactivitiestobedevelopedunderthisImplementingArrangement l-@,0 shallbemetinconformitywiththealreadymentionedworkingplansandmustbeinaccordwiththerulesandregulationsthatmayapplyineachCountry.  XB.` hp x (#XB  ARTICLEX 1/4 _ ENTRYINTOFORCE,TERMINATIONANDAMENDMENT  ,  X  ?+ ` hp x (#X? 1.  ThisImplementingArrangementshallenterintoforceuponitssignatureandshall  remaininforceforfiveyears.Itmaybeextendedoramendedbymutualagreementthroughtheexchangeofdiplomaticnotes.  XB.` hp x (#XB X?+ ` hp x (#X? 2.  ThisImplementingArrangementmaybeterminatedatanytimebyeitherPartycoming  intoeffectninety(90)daysafterreceiptofthepertinentdiplomaticnote.  XB.` hp x (#XB X?+ ` hp x (#X? 3.  Intheeventoftermination,thevalidityanddurationofongoingactivitiesshallnotbe | P  affected. T (   DoneattheU.S.DepartmentofAgriculture,Washington,DC,induplicate,onFebruary29,2000. `    FORTHEGOVERNMENTOF0  0(#(#0p(#(#FORTHEGOVERNMENTOFp(#p(# THE `     h      p THE  FEDERATIVEREPUBLICOF     p UNITEDSTATESOFAMERICA:  BRAZIL:"