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Guidance Documents

Welcome to the USDA Guidance Portal. This web portal is a searchable, indexed database that contains guidance documents issued by USDA and its agencies that are in effect today. The guidance documents contained herein lack the force and effect of law, unless expressly authorized by statute or incorporated into a contract. The USDA may not cite, use, or rely on any guidance that is not available through this guidance portal, except to establish historical facts. The Department reserves the right to remove any such documents at any time from this Portal.

USDA is continually updating its portal and agency websites to ensure that current guidance is on the portal and obsolete guidance is removed.

If you have feedback or problems accessing a guidance document, please contact USDAGuidance@usda.gov.

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Subject Issuing Agency Topic Latest Date Issued
VS CVB Notice 17-06 Option to Remove Back-Titration hamsters from In Vivo Potency Tests for Leptospira Serogroups Pomona and Grippotyphosa Veterinary Biologics February 5, 2026
VS CVB Notice 15-13 Option to Remove Back-Titration hamsters from In Vivo Potency Tests for Leptospira Serogroups Canicola and Icterohaemorragiae Veterinary Biologics February 5, 2026
VS CVB Notice 20-13 Use of Nonproprietary Names from the United States Adopted Names (USAN) Council as True Names for Veterinary Biologic Immunotherapeutics Veterinary Biologics February 5, 2026
VS CVB Notice 20-06 Virtual Inspections for Remodeled or New Facilities for Existing Licensed Establishments Veterinary Biologics February 5, 2026
VS CVB Notice 21-07 Updated Processes for Video Submission for Virtual Inspections Related to Remodeled or New Facilities for Existing Licensed Establishments Veterinary Biologics February 5, 2026
Option for Concurrent Confirmatory Testing of All Pre-license Serials Veterinary Biologics January 29, 2026
VS Memorandum 800.67 Shipment of Experimental Veterinary Biological Products Veterinary Biologics January 29, 2026
VS Memorandum 800.52 Export Certificates and Certificates of Licensing and Inspection for Animal Biological Products Veterinary Biologics January 21, 2026
VS Memorandum 800.97 Standard Reference Preparations, Test Reagents, and Seed Cultures for Laboratory Test Reagents Veterinary Biologics January 21, 2026
VS Memorandum 800.201 General Licensing Considerations: Backpassage Studies Veterinary Biologics January 21, 2026